Important Update
On April 14, the NIH sent Harvard University a Stop Work Order of the SMART IRB federal funding contract.
From the beginning, SMART IRB has been a collaborative, grassroots effort: SMART IRB was built by and for the community. It is not owned by Harvard, NIH, HHS, or any other entity.  At this time, Harvard is supporting the core team to maintain the Agreement and assist Participating Institutions to the best of our abilities. It is our intention to continue to provide this vital support to advance collaborative research. Please contact us for assistance.
Read Full Statement

User Guides

Points of Contact

Learn how IRB/HRPP administrators/staff and institutional leadership can join the SMART IRB Agreement, manage institutional profiles and user permissions, and track and document reliance arrangements.

Creating a SMART IRB User Account

Signing Reliance Agreement V3.0

Sending V3.0 to Institutional Official 

Managing Institutional Agreements 

Signing Optional V3.0 Indemnification

Sending Indemnification to Institutional Official 

Managing My Institution's Details/Profile

Updates to Institutional Details 

Key Points of Contact for Agreement V3.0 

Updates to Institutional  Profile 

Managing Reliance Requests

Create a New Reliance Request

Reliance Decision Making 

Requests for Edits 

Navigating Determination Letters 

Reliance Statuses

Managing User Accounts

User Dashboard 

Invite Users 

Activate Unconfirmed Users 

Deactivate Users 

Permissions

User Roles 

 User Permissions 

Cloning User Permissions