SMART IRB, the Streamlined, Multisite, Accelerated Resources for Trials IRB Reliance platform, is designed to harmonize and streamline the IRB review process for multisite studies, while ensuring a high level of protection for research participants. SMART IRB is funded by the National Center for Advancing Translational Sciences (NCATS) and intended to serve as a roadmap for institutions to implement The National Institutes of Health (NIH) Policy on the Use of a Single Institutional Review Board for Multi-Site Research.
SMART IRB began as a project called IRBrely, which was led by Dartmouth Synergy and funded by NCATS from September 2014 through April 2016. This collaborative effort built upon existing regional networks for IRB reliance to develop a master IRB reliance agreement and standard operating procedures (SOPs) suitable for use across the nation.
In July 2016, NCATS funded the next phase of work to enable IRB reliance on a national scale. This project is led by Harvard Catalyst, University of Wisconsin-Madison ICTR, and Dartmouth Synergy. SMART IRB is Funded by the NIH Clinical and Translational Science Awards (CTSA) Program through grant number UL1TR001102-04S1.
SMART IRB ambassadors are knowledgeable in the processes and practicalities of IRB reliance and are available to assist institutions in joining and implementing the SMART IRB Agreement. Learn more
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