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Getting Started with SMART IRB & the Online Reliance System

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Implementing the SMART IRB Agreement (for institutions and IRBs)

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The Benefits of SMART IRB

SMART IRB is a platform designed to ease common challenges associated with initiating multisite research and to provide a roadmap for institutions to implement the NIH Single IRB Review policy. Freely available for institutions and investigators, SMART IRB is an integrated, comprehensive platform that allows flexibility in the size and scope of collaboration to enable IRB reliance for multisite studies across the nation, regardless of funding status.

A roadmap to single IRB review

singlesource icon First step: Join SMART IRB
Streamline IRB review for multisite studies and eliminate the time and effort of negotiating IRB authorization agreements for each new study. Learn more about joining today.

online sharing icon Start Using the Online Reliance System for your studies
The Online Reliance System allows investigators and institution POCs to request, track, and document reliance arrangements on a study-by-study basis. Get started.

guidance icon Check out our SOPs, Templates, and Checklists
See our Resources page for a growing library of educational materials, tools, and checklists.

expertise icon Access Expertise across the Nation
Connect with a SMART IRB ambassador in your region. Institutions and IRBs can also request guidance through our consultation service.

Joining and using the SMART IRB platform is free; however, some institutions may charge IRB fees in connection with IRB Review activities.