NIH Funding for SMART IRB has resumed! We are grateful to our partners at NCATS and to the single IRB research community across the country for their advocacy, patience, and support during the funding pause. Read Latest Updates

SMART IRB

Supporting single IRB review and advancing collaborative research

SMART IRB eases challenges associated with multisite research by providing free, comprehensive support for single IRB (sIRB) arrangements. 

From small collaborations to large research networks, SMART IRB is designed to make multisite research work better for both IRB/HRPP personnel and research teams. Our educational resources, tools, templates, and guidance help Participating Institutions across the country improve efficiency, reduce burden, and advance research.

News and Events

SMART Talk

July 16, 2025

How Shall I Staff for Single IRB? Let Me Count the Ways…Exploring Models of Reliance Staffing

SMART IRB Reliance Agreement V3.0 is here!

Review and join the *new* SMART IRB Reliance Agreement.

Office Hours

Summer Series: Select Wednesdays

Updates, guidance, practical tips, and technical support.

A roadmap to single IRB review

Reliance Agreement

Streamlines IRB review and oversight for multisite studies and eliminates the time and effort of negotiating IRB authorization agreements for each study. Once your institution has joined, you may use the Agreement to support collaborations with Participating Institutions.

Reliance System

Allows institutions to join the Reliance Agreement and maintain their Institutional Profile. Provides a centralized system for investigators and institutions to request, track, and document reliance arrangements for their studies.

Resource Library

Browse, search, and sort SOPs, templates, checklists, tools, guidance, and more. These flexible resources are ready to use, easy to adapt, and designed to support IRB/HRPP staff, investigators, and study teams.

Learning Center

Education, on-demand training, and packaged resources to help investigators, study teams, and IRB/HRPP staff and institutions successfully plan for and navigate single IRB arrangements.

Investigators & Study Teams

Learn about your responsibilities related to single IRB and download start-up packages to help you plan your study and navigate IRB reliance arrangements.

IRB/HRPP Staff & Institutions

Learn about the roles and responsibilities of Reviewing IRBs and Relying Institutions and download start-up packages to help you implement the SMART IRB Agreement.

Featured Resource

Communication Plan

This form is helpful to guide conversations among the Reviewing IRB, Relying Institutions, and the Lead and Relying Site Study Teams.

SMART Talk

A monthly community forum

Wednesday, July 16, 2025

July 2025 SMART Talk: How Shall I Staff for Single IRB? Let Me Count the Ways…Exploring Models of Reliance Staffing

Harmonization

Recommendations for the Harmonization of Ancillary Reviews

Best practices for defining ancillary reviews and recommendations for centralizing reviews, timing, and allocating responsibilities in an sIRB context. Includes guidance and an implementation checklist.

Conflict of Interest Review Processes for sIRB Review

Addresses responsibilities of a Relying Institution and a Reviewing IRB/Reviewing IRB Institution in the COI review process, including FAQs and guidance for determining and managing COI.

Post-Approval Auditing for Studies Subject to Single IRB Review 

Identifies best practices and provides tools to support for-cause and not-for-cause audits in an sIRB context. Includes guidance, checklists, and a template report.

Support

Support Center

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