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Participating Institutions
including all CTSA hubs


We're Here to Help

Investigators: Submit/view a reliance request on the Online Reliance System.

IRB/HRPP Staff: Update institution information in Joinder; view pending requests in the Online Reliance System.


Representing regions throughout the US, ambassadors are available to assist institutions in joining and implementing the SMART IRB Agreement.

Find your ambassador

Expert Advice and Guidance

Prepare to serve as a Reviewing IRB or Relying Institution. We'll connect you with other IRBs experienced in the conduct, review, and oversight of multisite research.

Request a consultation

Help with another topic

If you have a question about SMART IRB or the Online Reliance System, check out the Support Center, or send an email to

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